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Little Guy 2 is a Little Guy Clone. He was originally voiced by the show's executive producer James Clayton. Since 2015, he has been voiced by actress Emma Stone. His first appearance is Wanted: The Great Drink Thief, where he allied with Little Guy, and the Little Guy Clones to stop Doctor (The Great Drink Thief).
He also appears in Greeny Phatom The Movie.
On July 21, 1993, Little Guy chased Bob Beanson into a mad scientist's laboratory near the Hollywood sign in Hollywood, California. They then ran into a cloning machine. With Little Guy and Bob Beanson's DNA in the machine, an exact copy of Little Guy was created, although some of Bob Beanson's DNA screwed up the cloning process which caused the clone to a Veronica colored shirt like Bob Beanson and Little Guy's personality respectively. They met this new creation of themselves and Bob Beanson got into a escape pod to 123 Greeny Phatom while Little Guy stayed. The first thing they did was go to 123 Greeny Phatom and drink lots of soda and eat lots of Cornelio Snacks for 12 hours straight.
- He has the same design as Little Guy's design, except that his clothes are purple (veronica).
- In Seasons 1-19, Little Guy 2 was originally voiced by the show's executive producer James Clayton before he died on a car accident during production of the 20th season of Greeny Phatom.
- Since Season 20, Little Guy 2 has been voiced by Emma Stone. She was chosen as the new voice actor for LG2 due to her low-pitched husky voice. Her husky voice is a result of having baby colic, a condition of chronic crying as an infant, resulting in the development of nodules. She has calluses on her vocal cords as an adult. This has resulted in a case of "crossdressing voices".
- In Greeny Phatom The Movie and some post-movie episodes, Little Guy 2 is alternatively voiced by Owen Wilson. He is in the role when either James Clayton or Emma Stone is not available to record Greeny Phatom episodes.
- He is the very first Little Guy clone to be created by his owner Little Guy.
- He is also the first Little Guy clone to wear different clothing.